Formation of N-nitrosodimethylamine during the Storage of ranitidine reagent powder

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Temperature-dependent formation of N-nitrosodimethylamine in the course of the storage of ranitidine reagent powders and tablets

The aim of this research was to elucidate the impact of high-temperature storage on the steadiness of ranitidine, particularly with respect to the potential formation of N-nitrosodimethylamine (NDMA), which is classed as a possible human carcinogen.
Commercially obtainable ranitidine reagent powders and formulations have been saved beneath numerous situations, and subjected to LC-MS/MS evaluation. When ranitidine tablets from two completely different manufacturers (designated as pill A and pill B) have been saved beneath accelerated situation (40°C with 75% relative humidity), following the drug stability pointers issued by the Worldwide Convention on Harmonisation (ICH-Q1A), for as much as eight weeks, the quantity of NDMA in them considerably elevated from 0.19 to 116 ppm and from 2.89 to 18 ppm, respectively.
The formation of NDMA that exceeded the appropriate each day consumption restrict (0.32 ppm) on the temperature used beneath accelerated storage situations clearly highlights the danger of NDMA formation in ranitidine formulations when extrapolated to storage beneath ambient situations.
A forced-degradation research beneath the stress situation (60°C for 1 week) strongly instructed that environmental elements comparable to moisture and oxygen are concerned within the formation of NDMA in ranitidine formulations. Storage of ranitidine tablets and reagent powders on the excessive temperatures additionally elevated the quantity of nitrite, which is taken into account one of many elements influencing NDMA formation.
These information point out the need of controlling/monitoring stability-related elements, along with controlling impurities in the course of the manufacturing course of, with a view to mitigate nitrosamine-related well being dangers of sure prescribed drugs.

Bovine Serum Albumin ? Heat Shock, Reagent Grade, pH 7.0

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Albumin Depletion Reagent for Plasma and Serum (20 ml)

P5W13 - Ask for price

EZ-DNA Reagents

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Ecl Detection Reagents

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Human Serum (CRP free)

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REAGENTS HIGH RANGE AMMONIA

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Set of 10 Biolipidure Reagents

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Description: Set of 10 Biolipidure Reagents, whose applications include Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

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Serum Albumin, Lipid Free Protein

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Bovine Serum Albumin, protease free

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Bovine Serum Albumin, protease free

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Bovine Serum Albumin, protease free

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Serum Free Medium (Type II) For Mouse Embryonic Stem Cells

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Bradford(Coomassie) Protein Assay Plus Reagents

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Corning Lymphocyte Serum Free Medium KBM551

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Corning Lymphocyte Serum Free Medium KBM581

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Fetal Bovine Serum, Premium Tetracyclin Free

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Serum Free Medium For Rat Neural Stem Cells

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Bovine Serum Albumin ? Heat Shock, Protease Free, pH 7.0

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Xpro IP Cell Lysis Reagent,SDS Free

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Bifunctional Reagents for Formylglycine Conjugation: Pitfalls and Breakthroughs

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Due to this fact, functionalized clickable HIPS and tandem Knoevenagel constructing blocks have been synthesized, conjugated to small proteins (DARPins) and subsequently linked to strained alkyne-containing payloads for protein labeling. This process allowed the selective bioconjugation of 1 or two DBCO-carrying payloads with almost stoichiometric quantities at low concentrations.
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Buzz about RT-qPCR: An RT-qPCR formulation for SARS-CoV-2 detection utilizing reagents produced at Georgia Institute of Know-how

Albumin Depletion Reagent for Plasma and Serum (20 ml)

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Rabbit Serum NS TH YG 500mL

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EUR 228.07

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Rabbit Serum (Non-Sterile

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  • EUR 1296.00
  • EUR 2966.40
  • EUR 794.40
  • 100 ml
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EUR 5137.2

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EUR 199.68

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EUR 371.63

Rabbit Serum S TH YG HI 500mL

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Monoclonal BSA (Bovine Serum Albumin) Antibody - Without BSA and Azide, Clone: SPM376

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E04S0273-192T 192 tests
EUR 1524
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Rabbit Serum Iron ELISA kit

E04S0273-48 1 plate of 48 wells
EUR 624
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E04S0273-96 1 plate of 96 wells
EUR 822
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Monoclonal BSA (Bovine Serum Albumin) Antibody - Without BSA and Azide, Clone: ALB/398

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Rabbit Serum NS NH YG 3L

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EUR 1524
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E04S0014-48 1 plate of 48 wells
EUR 624
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EUR 822
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E04S0228-192T 192 tests
EUR 1524
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EUR 624
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NRS01 200 µl
EUR 358.8

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Rabbit Serum NH S DELIPID. 500mL

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EUR 358.57

EZ-DNA Reagents

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EUR 105.67

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EUR 112.2

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Rabbit Anti-Sheep IgG (H+L)-FITC conjugate (adsorbed with multispecies serum)

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Rabbit Serum Albumin Polyclonal Antibody

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  • EUR 684.66
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Rabbit Serum Amyloid A (SAA) Protein

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  • EUR 777.60
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Normal Rabbit Serum | RS-15-100ML

RS-15-100ML 100 mL
EUR 420
Description:

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anti-Rpn3 (yeast) antibody, rabbit serum

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EUR 543.6
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EUR 1524
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E04S0304-48 1 plate of 48 wells
EUR 624
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E04S0304-96 1 plate of 96 wells
EUR 822
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Sterile filtered rabbit serum, 0.2 micron

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EUR 207.48

Sterile filtered rabbit serum, 0.2 micron

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Bovine Serum Albumin / BSA Rabbit mAb

A11625-100ul 100 ul
EUR 492

Bovine Serum Albumin / BSA Rabbit mAb

A11625-200ul 200 ul
EUR 685.2

Bovine Serum Albumin / BSA Rabbit mAb

A11625-20ul 20 ul
EUR 265.2

Bovine Serum Albumin / BSA Rabbit mAb

A11625-50ul 50 ul
EUR 344.4

anti-Rad18 (human) antibody, rabbit serum

70-023 50uL
EUR 496.8
Description: The anti-Rad18 (human) antibody, rabbit serum is available in Europe and for worldwide shipping via Gentaur.

Rabbit Serum Amyloid A (SAA) CLIA Kit

20-abx190777
  • EUR 10131.60
  • EUR 5396.40
  • EUR 1243.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rabbit Serum amyloid A 3 ELISA kit

E04S0229-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Serum amyloid A 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Serum amyloid A 3 ELISA kit

E04S0229-48 1 plate of 48 wells
EUR 624
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Rabbit Serum amyloid A 3 ELISA kit

E04S0229-96 1 plate of 96 wells
EUR 822
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Rabbit Serum Amyloid A (SAA)CLIA Kit

SCA885Rb-10x96wellstestplate 10x96-wells test plate
EUR 7342.85
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rabbit serum Amyloid A (SAA) in serum, plasma and other biological fluids.

Rabbit Serum Amyloid A (SAA)CLIA Kit

SCA885Rb-1x48wellstestplate 1x48-wells test plate
EUR 709.88
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rabbit serum Amyloid A (SAA) in serum, plasma and other biological fluids.

Rabbit Serum Amyloid A (SAA)CLIA Kit

SCA885Rb-1x96wellstestplate 1x96-wells test plate
EUR 962.69
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Rabbit Serum Amyloid A (SAA)CLIA Kit

SCA885Rb-5x96wellstestplate 5x96-wells test plate
EUR 3972.1
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rabbit serum Amyloid A (SAA) in serum, plasma and other biological fluids.

Rabbit Serum Amyloid A (SAA) CLIA Kit

4-SCA885Rb
  • EUR 7404.00
  • EUR 3973.20
  • EUR 963.60
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Rabbit Serum Amyloid A (SAA)Serum, plasma and other biological fluids

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EUR 481.2
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